Journal
PERFUSION-UK
Volume 23, Issue 4, Pages 231-235Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0267659108100708
Keywords
cardiac; echocardiogram; extracellular matrix; fibrosis; remodeling; beta-adrenergic
Funding
- NHLBI NIH HHS [R01 HL079206-01] Funding Source: Medline
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Isoproterenol (Iso) was a clinical therapeutic that is now used as a research means for the induction of cardiac hypertrophy. Currently, dobutamine (Dob) has replaced Iso as the preferred inotropic beta-adrenergic agent to wean patients from cardiopulmonary bypass and to sustain adequate cardiac function during the postoperative period. We sought to compare the cardiac structural and functional effects of long-term administration (7days) of Iso with Dob at a dose of 40 mu g/mouse/day in 12-week-old C57BL/6 female mice. Cardiac function was determined with transthoracic echo cardiography (ECHO) 24 hours after the last dose. Cardiac wet weights increased 33% and 24% in the Iso and Dob groups compared with controls (p < 0.05). Dob and Iso significantly increased cardiac fibrosis and decreased cardiac function with chronic administration. Administration also resulted in increased left atrial size, suggesting that both Dob and Iso decreased LV compliance, but did not induce heart failure. In conclusion, chronic administration of Dob may have a detrimental effect on cardiac structure and function. Perfusion (2008) 23, 231-235.
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