Journal
PEPTIDES
Volume 109, Issue -, Pages 14-22Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2018.09.008
Keywords
NUCB2/nesfatin-1; CCK; Feeding behavior; Appetite regulation; Siberian sturgeon
Funding
- Major Project of the Education Department in Sichuan [12ZA120]
- Double Branch Plan of Sichuan Agricultural University [03571762]
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Nesfatin-1 is an 82-amino acid protein derived from nucleobindin 2 (NUCB2), which could inhibit food intake in fish and mammals. However, the neuroendocrine mechanism of nesfatin-1 in animal appetite regulation is unclear. To explore the feeding mechanism of nesfatin-1 in Siberian sturgeon (Acipenser baerii), intraperitoneal injections of nesfatin-1 and sulfated cholecystokinin octapeptide (CCK8), Lorglumide (CCK1R selective antagonist), or LY 225,910 (CCK2R selective antagonist) were performed. Co-injection of nesfatin-1 and CCK8 synergistically significantly decreased the food intake in 1 h. Lorglumide reversed the anorectic effect of nesfatin-1, but LY 225,910 had no effect. Moreover, Lorglumide could also reverse the expressions of appetite factors including nucb2, cck, unc3, cart, apelin, pyy, and npy induced by nesfatin-1 in the brain, stomach, and liver, while LY 225,910 partially reversed these changes. These results indicate that nesfatin-1 inhibits the appetite of Siberian sturgeon mainly through the CCK - CCK1R signaling pathway.
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