Journal
PEPTIDES
Volume 62, Issue -, Pages 197-202Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2014.09.018
Keywords
Blood-brain barrier; Alpha-synuclein; LRP-1; p-Glycoprotein; Parkinson's disease
Funding
- NIN [U01 N5082137]
- VA Merit Review
- NIH [AG029834 (WAB)]
Ask authors/readers for more resources
Alpha-synuclein (alpha-Syn), a small protein with multiple physiological and pathological functions, is one of the dominant proteins found in Lewy Bodies, a pathological hallmark of Lewy body disorders, including Parkinson's disease (PD). More recently, alpha-Syn has been found in body fluids, including blood and cerebrospinal fluid, and is likely produced by both peripheral tissues and the central nervous system. Exchange of alpha-Syn between the brain and peripheral tissues could have important pathophysiologic and therapeutic implications. However, little is known about the ability of alpha-Syn to cross the blood-brain barrier (BBB). Here, we found that radioactively labeled alpha-Syn crossed the BBB in both the brain-to-blood and the blood-to-brain directions at rates consistent with saturable mechanisms. Low-density lipoprotein receptor-related protein-1 (LRP-1), but not p-glycoprotein, may be involved in alpha-Syn efflux and lipopolysaccharide (LPS)-induced inflammation could increase alpha-Syn uptake by the brain by disrupting the BBB. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available