Journal
PEPTIDES
Volume 45, Issue -, Pages 22-27Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2013.04.007
Keywords
Obesity; NPY variants; Metabolic syndrome features; Children
Funding
- Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria [PI 020826, PI051968]
- Conserjeria de Innovacion y Ciencia, Junta de Andalucia [P06-CTS 2203]
- Ministerio de Universidades y Tecnologia, Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias, Redestematicas de investigacion cooperativa RETIC [Red SAMID RD08/0072/0028]
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Variants in the neuropeptide Y (NPY) gene have been associated with obesity and its traits. The objective of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the NPY gene with obesity, metabolic syndrome features, and inflammatory and cardiovascular disease (CVD) risk biomarkers in Spanish children. We recruited 292 obese children and 242 normal-body mass index (BMI) children. Height, weight, BMI, waist circumference, clinical and metabolic markers, adipokines, and inflammatory (PCR, IL-6, IL-8 and TNF-alpha) and CVD risk biomarkers (MPO, MMP-9, sE-selectin, sVCAM, sICAM, and PAI-1) were analyzed. Seven SNPs in the NPY gene were genotyped. The results of our study indicate that anthropometric measurements, clinical and metabolic markers, adipokines (leptin and resistin), and inflammatory and CVD risk biomarkers were generally elevated in the obese group. The exceptions to this finding included cholesterol, HDL-c, and adiponectin, which were lower in the obese group, and glucose, LDL-c, and MMP-9, which did not differ between the groups. Both rs16147 and rs16131 were associated with the risk of obesity, and the latter was also associated with insulin resistance, triacylglycerols, leptin, and HDL-c. Thus, we confirm the association of rs16147 with obesity, and we demonstrate for the first time the association of rs16131 with obesity and its possible impact on the early onset of metabolic syndrome features, mainly triacylglycerols, in children. (c) 2013 Elsevier Inc. All rights reserved.
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