Journal
PEPTIDES
Volume 34, Issue 2, Pages 349-352Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2012.02.008
Keywords
Diabetes; Retina; Nitric oxide; Kallikrein; Na/K ATPase; Vascular permeability; Streptozotocin; Bradykinin B-1 receptor; R-954
Funding
- University Argentina John F Kennedy
- University Del Salvador-AOA
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The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeability measured as plasma extravasation, and decreases of Na/K ATPase activity in diabetic rat retina 4 and 12 weeks after streptozotocin (STZ) injection. Treatment of the animals for 5 consecutive days with a novel selective bradykinin B-1 receptor (BKB1-R) antagonist R-954 (2 mg/kg s.c) at the end of the 4 and 12 week periods highly reduced NO, kallikrein and capillary permeability and increased Na/K ATPase activity in the retina. These results suggest that the BKB1-R receptor subtype is over-expressed during the streptozotocin-induced development of diabetes in rat retina as evidenced by the inhibitory effects of the BKB1-R antagonist R-954 on NO, kallikrein and vascular permeability increases as well as Na/K ATPase decreases. The beneficial role of the BKB1-R antagonist R-954 for the treatment of the diabetic retinopathy is also suggested. (C) 2012 Elsevier Inc. All rights reserved.
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