Journal
PEPTIDES
Volume 32, Issue 4, Pages 832-834Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2011.01.003
Keywords
Microcin; Mitochondria; RNA-polymerase; Apoptosis
Funding
- CONICET [PIP 4996]
- CIUNT [26/D228]
- Agencia Nacional de Promocion Cientifica y Tecnica [PICTO 843, PAE 22642]
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MccJ25, an antimicrobial peptide, was unable to cause apoptosis of COS-7 cells in spite of inducing reactive-oxygen species overproduction as well as cytochrome c release from isolated mitochondria. Surprisingly, MccJ25-Ga, an amidated variant of MccJ25 that displays similar anti-mitochondrial effects, did induce apoptosis in COS-7. The only difference found between the activities of these peptides was the unpredicted inhibition of mitochondrial RNA synthesis by MccJ25-Ga. These results led us to hypothesize that both mitochondrial RNA polymerase and mitochondrial membrane might be the molecular targets of MccJ25-Ga in mitochondria and this combined effect may lead to apoptosis. (C) 2011 Elsevier Inc. All rights reserved.
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