Journal
PEPTIDES
Volume 32, Issue 4, Pages 639-647Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2011.01.009
Keywords
Seaweed pipefish; Oxidative stress; Antioxidant; Reactive oxygen species; NP-kappa B
Funding
- Ministry of Land, Transport and Maritime, Republic of Korea
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Two new peptides derived from seaweed pipefish Syngnathus schlegeli, SPP-1(QLGNLGV) and SPP-2 (SVM-PVVA) were assessed for their ability to prevent hydrogen peroxide induced oxidative stress in human dermal fibroblasts (HDFs). Both peptides showed a significant hydroxyl radical scavenging activity when tested by ESR technique. And also the peptides effectively suppressed the hydrogen peroxide induced ROS production and DNA damage in HDF cells. Furthermore the two peptides increase the protein expression levels of intracellular antioxidant enzymes SOD1, GSH and catalase in hydrogen peroxide stressed HDF cells At the cellular signaling level. SPPs block the NF-kappa B activation which may lead to the reduction of oxidative stress mediated damage of HDF cells. These finding indicate the potential antioxidant effects of SPPs as response to H2O2 stimulation. (C) 2011 Elsevier Inc. All rights reserved.
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