Journal
PEPTIDES
Volume 32, Issue 11, Pages 2242-2247Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2011.05.006
Keywords
Ghrelin; Teleost fish; Goldfish; Feeding regulation; Locomotor activity; Energy balance
Funding
- Japan Society for the Promotion of Science
- University of Toyama
- Mishima Kaiun Memorial Foundation
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Ghrelin was first identified and characterized from rat stomach as an endogenous ligand for the growth hormone secretagogue receptor. Ghrelin and its receptor system are present not only in peripheral tissues such as stomach and intestine, but also in the central nervous system of mammals. Interestingly, administration of ghrelin induces an orexigenic effect and also modifies locomotor activity, suggesting its involvement in feeding control and the regulation of energy balance, in addition to the regulation of growth hormone release. Information about ghrelin in non-mammals, such as teleost fish, has also been increasing, and important data have been obtained. An understanding of the evolutionary background of the energy regulation system and the central and peripheral roles of ghrelin in teleost fish could provide indications as to their roles in mammals, particularly humans. In this review, we overview the central and peripheral effects of ghrelin on energy balance, locomotor activity, and lipid metabolism in teleost fish. (C) 2011 Elsevier Inc. All rights reserved.
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