Journal
PEPTIDES
Volume 32, Issue 11, Pages 2265-2273Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2011.05.016
Keywords
Ghrelin; Food reward; Food motivation; Interaction; Neurocircuitry; Obesity; Food intake control
Funding
- Swedish Research Council for Medicine [2009-S266]
- European Commission [FP7-HEALTH-2009-241592, FP7-KBBE-2009-3-245009, FP7-KBBE-2010-4-266408]
- FOU/ALF Goteborg [ALFGBG-138741]
- Swedish Foundation [A305-188]
- Swedish Institute for Strategic Research [A305-188]
- Swedish Institute
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The incidence of obesity is increasing at an alarming rate and this worldwide epidemic represents a significant decrease in life span and quality of life of a large part of the affected population. Therefore an understanding of mechanisms underlying food overconsumption and obesity development is urgent and essential to find potential treatments. Research investigating mechanisms underlying obesity and the control of food intake has recently experienced a major shift in focus, from the brain's hypothalamus to additional important neural circuits controlling emotion, cognition and motivated behavior. Among them, the mesolimbic system, and the changes in reward and motivated behavior for food, emerge as new promising treatment targets. Furthermore, there is also growing appreciation of the impact of peripheral hormones that signal nutrition status to the mesolimbic areas, and especially the only known circulating orexigenic hormone, ghrelin. This review article provides a synthesis of recent evidence concerning the impact of manipulation of ghrelin and its receptor on models of food reward/food motivation behavior and the mesolimbic circuitry. Particular attention is given to the potential neurocircuitry and neurotransmitter systems downstream of ghrelin's effects on food reward. (C) 2011 Published by Elsevier Inc.
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