Journal
PEPTIDES
Volume 30, Issue 11, Pages 2040-2044Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2009.05.002
Keywords
Melanin-concentrating hormone; MCHR1; Appetite; Obesity
Funding
- National Institutes of Health [DK56113, DK56116]
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Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy expenditure in rodent models, and the central sites where MCH acts in regulating energy homeostasis. Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research. (c) 2009 Elsevier Inc. All rights reserved.
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