Journal
PEPTIDES
Volume 30, Issue 1, Pages 67-75Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2008.06.029
Keywords
Rhesus monkey; Puberty; GnRH pulse generator; Feedback loops; GPR54 downregulation
Funding
- National Institutes of Health [HD 13254, HD 08610]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P30HD008610, U54HD008610, R01HD013254] Funding Source: NIH RePORTER
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The present article reviews recent studies of monkeys and, in some cases, humans that have been conducted to examine the role of kisspeptin-GPR54 signaling in the regulation of the hypothalamic-pituitary-gonadal axis in higher primates. This area of peptide biology was initiated in 2003 by the discovery that loss of function mutations of GPR54 in man were associated with hypogonadotropic hypogonadism and absent or delayed puberty. Puberty in the monkey, an experimental model commonly used to study this fundamental developmental stage, is first described. This is followed by a review of the role of kisspeptin in the regulation of the postnatal ontogeny of GnRH pulsatility. The roles of kisspeptin in GnRH pulse generation and in the feedback loops governing gonadotropin secretion in primates are then discussed. A brief section on kisspeptin-GPR54 signaling at the pituitary and gonadal levels is also included. The review concludes with a discussion of the phenomenon of GPR54 downregulation by continuous exposure to kisspeptin and its therapeutic implications. (C) 2008 Elsevier Inc. All rights reserved.
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