Journal
PEPTIDES
Volume 30, Issue 9, Pages 1742-1745Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2009.06.016
Keywords
Obestatin; Ghrelin; Pregnancy; Hypertension
Funding
- National Natural Science Foundation of China [30800375, 30670760, 30700380]
- Major State Basic Research Development Program of the People's Republic of China [2006CB503807]
Ask authors/readers for more resources
Obestatin is a recently discovered 23-amino acid peptide encoded by the same gene that encodes ghrelin. it has been reported that there is a significant negative correlation between the plasma ghrelin concentration and systemic blood pressure in patients with pregnancy-induced hypertension. We investigated the plasma concentration of obestatin in 18 non-pregnant women, 18 normal pregnant women, and 15 patients with pregnancy-induced hypertension. The plasma concentrations of obestatin in these 3 groups of women were 63.4 +/- 9.5 pg/ml, 38.1 +/- 6.3 pg/ml, and 46.0 +/- 9.3 pg/mJ, respectively. In non-pregnant women, there was no correlation between the plasma obestatin concentration and the mean arterial pressure. However. there was a positive correlation between the plasma obestatin concentration and the mean arterial pressure in normal pregnant women and pregnant women with pregnancy-induced hypertension. These results suggest that obestatin may have some potential role in the regulation of blood pressure in normal pregnant women and women with pregnancy-induced hypertension. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available