Journal
PEDIATRICS INTERNATIONAL
Volume 56, Issue 6, Pages 851-855Publisher
WILEY
DOI: 10.1111/ped.12376
Keywords
C-reactive protein; interleukin-6; periventricular leukomalacia; premature infant; white matter injury
Categories
Ask authors/readers for more resources
BackgroundThe aim of this study was to determine whether patterns of increases in serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels at birth were associated with the development of white matter injury (WMI) in preterm infants with a fetal inflammatory response (FIR). MethodsOne hundred infants who were born at <32 weeks gestation and had funisitis, as determined by histological evidence of FIR, were studied. Infants were divided into four groups according to IL-6 and CRP levels at birth, with cut-off values of 200pg/mL and 0.4mg/dL, respectively. We compared the incidence of WMI, determined by MRI at term-equivalent age, among these groups. ResultsThe number of infants in each group was 12, 43, 0, and 45 in the high IL-6 and high CRP (HH) group, high IL-6 and low CRP (HL) group, low IL-6 and high CRP (LH) group, and low IL-6 and low CRP (LL) group, respectively. The incidence of WMI was significantly higher in the HH group than in the HL group and LL group (83%, 40%, and 34%, respectively). Multiple logistic regression analysis revealed that a combined elevation in IL-6 and CRP levels was an independent predictor for the development of WMI (odds ratio, 8.3). ConclusionA combined elevation in serum IL-6 and CRP levels at birth was associated with the development of WMI in preterm infants with FIR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available