Effect of Prenatal Selenium Supplementation on Cord Blood Selenium and Lipid Profile

Background: Selenium is an essential trace element and as a component of selenoproteins it plays a key role as an antioxidant. We aimed to evaluate the effect of selenium supplementation during pregnancy on cord blood selenium content and lipid profile. Methods: This trial was performed on 166 eligible women who were randomized to receive 100 mu g of selenium, as selenium-yeast (Se group) or a placebo-yeast tablet (placebo group). Umbilical cord blood samples were collected at the time of delivery and selenium concentration and lipid profile were measured. Results: Triglyceride levels were found to be significantly higher in the Se group than in the placebo group (p = 0.01). However, no significant difference in cord blood selenium was observed between the groups nor were there any significant correlations between cord blood selenium and lipid profile parameters. Conclusion: Our findings suggest that selenium supplementation in pregnant women may be associated with an increased cord-blood triglyceride level, although total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol levels did not change significantly. The clinical significance of the increased cord triglyceride concentration needs to be evaluated. Copyright (C) 2012, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.