Journal
TRENDS IN PLANT SCIENCE
Volume 20, Issue 10, Pages 614-621Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2015.07.005
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Funding
- French Agence Nationale de la Recherche [ANR-12-BSV6-0010]
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Histone lysine acetylation is well known for being important in the epigenetic regulation of gene expression in eukaryotic cells. Recent studies have uncovered a plethora of acetylated proteins involved in important metabolic pathways, such as photosynthesis and respiration in plants. Enzymes involved in histone acetylation and deacetylation are being identified as regulators of acetylation of metabolic enzymes. Importantly, key metabolites, such as acetyl-CoA and NAD(+), are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyl-transferases (HAT) and deacetylases (HDAC). Further research is required to determine whether and how HATs and HDACs sense cellular metabolite signals to control gene expression and metabolic enzyme activity through lysine acetylation and deacetylation.
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