Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 36, Issue 8, Pages 537-546Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2015.05.003
Keywords
alginate; microcapsules; cell transplantation; drug delivery; allografts
Categories
Ask authors/readers for more resources
Treating many chronic diseases will require a tight, minute-to-minute regulation of therapeutic molecules that is currently not achievable with most pharmaceutical therapies. For these diseases, implantable living cellular systems may be able to provide unlimited drug delivery, enabling seamless matching of treatment duration with disease longevity. Cell encapsulation is an advanced technology that achieves this goal and represents a viable therapeutic option. The advanced state of the field has allowed researchers to inch forward into therapeutic domains previously untouchable because of the myriad disparate fields that intersect biomaterials and cells. Here, we discuss the next generation of clinical trials and potential approaches, 'smart' and responsive encapsulation systems, sophisticated and multifunctional devices, and novel imaging tools, together with the future challenges in the field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available