Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 36, Issue 6, Pages 349-359Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2015.04.001
Keywords
metastasis; epithelial-mesenchymal plasticity; cancer stem cell; circulating tumor cell; therapy resistance
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Funding
- US National Institutes of Health [R01CA166051, R01CA181029]
- Cancer Prevention and Research Institute of Texas [R1004, RP150319]
- Jeanne F. Shelby Scholarship Fund
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Metastasis is a 100-year-old research topic. Technological advances during the past few decades have led to significant progress in our understanding of metastatic disease. However, metastasis remains the leading cause of cancer-related mortalities. The lack of appropriate clinical trials for metastasis preventive drugs and incomplete understanding of the molecular machinery are major obstacles in metastasis prevention and treatment. Numerous processes, factors, and signaling pathways are involved in regulating metastasis. Here we discuss recent progress in metastasis research, including epithelial-mesenchymal plasticity, cancer stem cells, emerging molecular determinants and therapeutic targets, and the link between metastasis and therapy resistance.
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