Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 36, Issue 5, Pages 270-276Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2015.03.004
Keywords
retrograde menstruation; inflammatory pain; neurogenic inflammation; sensory nerves; endometriosis
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Endometriosis is a chronic, hormone-dependent, inflammatory disease, characterized by the presence and growth of endometrial tissue outside the uterine cavity. It affects 5-10% of the female population of reproductive age and is frequently associated with moderate to severe pain, subfertility, and a marked reduction in healthrelated quality of life. Here, we propose a new pathophysiological concept of endometriosis, summarizing recent findings in one unifying picture. We propose menstruating tissue as the trigger for inflammatory pain in endometriosis through the activation of innate immune cells and peripheral nerve endings. We speculate how innovative treatment modalities beyond hormonal treatment will improve patients' lives.
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