Journal
PEDIATRICS
Volume 133, Issue 1, Pages 171-174Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2013-3442
Keywords
respiratory distress syndrome; preterm infant; neonate; surfactant; continuous positive airway pressure; bronchopulmonary dysplasia
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Current practice guidelines recommend administration of surfactant at or soon after birth in preterm infants with respiratory distress syndrome. However, recent multicenter randomized controlled trials indicate that early use of continuous positive airway pressure with subsequent selective surfactant administration in extremely preterm infants results in lower rates of bronchopulmonary dysplasia/death when compared with treatment with prophylactic or early surfactant therapy. Continuous positive airway pressure started at or soon after birth with subsequent selective surfactant administration may be considered as an alternative to routine intubation with prophylactic or early surfactant administration in preterm infants.
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