Journal
PEDIATRICS
Volume 133, Issue 1, Pages 164-170Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2013-3444
Keywords
inhaled nitric oxide; preterm infants; hypoxic respiratory failure; bronchopulmonary dysplasia
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Nitric oxide, an important signaling molecule with multiple regulatory effects throughout the body, is an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn and hypoxemic respiratory failure. Several randomized controlled trials have evaluated its role in the management of preterm infants <= 34 weeks' gestational age with varying results. The purpose of this clinical report is to summarize the existing evidence for the use of inhaled nitric oxide in preterm infants and provide guidance regarding its use in this population.
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