Journal
TRENDS IN PARASITOLOGY
Volume 31, Issue 3, Pages 100-108Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2014.12.012
Keywords
leishmaniases; Leishmania infantum; high-throughput sequencing; genome; transcriptome; bioinformatics; sand fly; metazoonosis; host-parasite interactions; One Health
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Funding
- Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge Joint Research Grants Scheme
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It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite-host-vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the 'One Health' concept may open new avenues for the control of these devastating diseases. Burden of leishmaniasis and the need for a 'One Health' initiative
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