Journal
PEDIATRICS
Volume 129, Issue 5, Pages E1121-E1128Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2011-2583
Keywords
autism; developmental delay; diabetes; epidemiology; hypertension; obesity
Categories
Funding
- National Institutes of Health [P01 ES11269, R01 ES015359]
- US Environmental Protection Agency [R829388, R833292]
- MIND Institute, University of California Davis
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WHAT'S KNOWN ON THIS SUBJECT: Diabetes during pregnancy has been associated with general development impairments in offspring; however, associations between autism and maternal diabetes have been inconsistent. Few studies have examined related conditions accompanied by underlying increased insulin resistance and their association with developmental outcomes. WHAT THIS STUDY ADDS: This population-based study in young children provides evidence that maternal metabolic conditions are a risk factor for autism, developmental delay without autistic symptoms, and impairments in several domains of development, particularly expressive language, after adjusting for sociodemographic and other characteristics.
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