Journal
TRENDS IN NEUROSCIENCES
Volume 38, Issue 12, Pages 751-762Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2015.10.005
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Funding
- Howard Hughes Medical Institute
- National Institutes of Health (NIH) [R37NS039996]
- NIH [R01NS078164, R01MH101268]
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Homeosis is classically defined as the transformation of one body part into something that resembles another body part. We propose here to broaden the concept of homeosis to the many neuronal cell identity transformations that have been uncovered over the past few years upon removal of specific regulatory factors in organisms from Caenorhabditis elegans to Drosophila, zebrafish, and mice. The concept of homeosis provides a framework for the evolution of cell type diversity in the brain.
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