Journal
TRENDS IN NEUROSCIENCES
Volume 38, Issue 9, Pages 560-570Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2015.07.004
Keywords
hippocampus; sharp-wave ripples; replay; synaptic plasticity; dopamine; acetylcholine
Categories
Funding
- Engineering and Physical Sciences Research Council UK
- Eli Lilly Company
- Medical Research Council UK
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council UK
- Biotechnology and Biological Sciences Research Council [BB/K000454/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1280505] Funding Source: researchfish
- Medical Research Council [984420, MC_UU_12024/3] Funding Source: researchfish
- Wellcome Trust [101029/Z/13/Z] Funding Source: researchfish
- Wellcome Trust [101029/Z/13/Z] Funding Source: Wellcome Trust
- BBSRC [BB/K000454/1] Funding Source: UKRI
- MRC [MC_UU_12024/3] Funding Source: UKRI
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The consolidation of memories for places and events is thought to rely, at the network level, on the replay of spatially tuned neuronal firing patterns representing discrete places and spatial trajectories. This occurs in the hippocampal-entorhinal circuit during sharp wave ripple events (SWRs) that occur during sleep or rest. Here, we review theoretical models of lingering place cell excitability and behaviorally induced synaptic plasticity within cell assemblies to explain which sequences or places are replayed. We further provide new insights into how fluctuations in cholinergic tone during different behavioral states might shape the direction of replay and how dopaminergic release in response to novelty or reward can modulate which cell assemblies are replayed.
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