Journal
TRENDS IN NEUROSCIENCES
Volume 38, Issue 9, Pages 524-534Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2015.07.008
Keywords
inhibition; GABAergic plasticity; neocortex; retrograde signaling
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Funding
- Giovanni Armenise-Harvard Foundation
- European Research Council (ERC) under the European Commission 7th Framework Programmme/ERC grant [200808]
- Investissements d'Avenir [ANR-10-IAIHU-06]
- Agence Nationale de la Recherche [ANR-13-BSV4-0015-01]
- ICM (Paris)
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV4-0015] Funding Source: Agence Nationale de la Recherche (ANR)
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In the neocortex, different types of excitatory and inhibitory neurons connect to one another following a detailed blueprint, defining functionally-distinct subnetworks, whose activity and modulation underlie complex cognitive functions. We review the cell-autonomous plasticity of perisomatic inhibition onto principal excitatory neurons. We propose that the tendency of different cortical layers to exhibit depression or potentiation of perisomatic inhibition is dictated by the specific identities of principal neurons (PNs). These are mainly defined by their projection targets and by their preference to be innervated by specific perisomatic-targeting basket cell types. Therefore, principal neurons responsible for relaying information to subcortical nuclei are differentially inhibited and show specific forms of plasticity compared to other PNs that are specialized in more associative functions.
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