Journal
TRENDS IN MOLECULAR MEDICINE
Volume 21, Issue 2, Pages 60-67Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.12.009
Keywords
uterine natural killer cells; maternal tolerance; fetal growth; allorecognition
Funding
- Wellcome Trust
- Medical Research Council
- Centre for Trophoblast Research
- Medical Research Council [G0900101] Funding Source: researchfish
- MRC [G0900101] Funding Source: UKRI
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Much research in reproductive immunology is preoccupied with maternal tolerance of the semi-allogeneic fetus. This inevitably leads to the assumption that the maternal immune system should be suppressed, similarly to the immunosuppression needed to avoid rejection of an allograft. However, the parallels with transplantation immunology are misleading, and we discuss how interactions between variable immune system genes expressed on maternal natural killer (NK) cells and on the fetal trophoblast modulate fetal growth. Exaggerated suppression or activation of maternal NK cells associates with both extremes of birth weight.
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