Journal
TRENDS IN MOLECULAR MEDICINE
Volume 21, Issue 2, Pages 88-97Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.11.009
Keywords
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Funding
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Canada
- Women and Children's Health Research Institute through Stollery Children's Hospital Foundation
- Royal Alexandra Hospital Foundation
- American Heart Association [13SDG17050056]
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In preeclampsia, as a heterogeneous syndrome, multiple pathways have been proposed for both the causal as well as the perpetuating factors leading to maternal vascular dysfunction. Postulated mechanisms include imbalance in the bioavailability and activity of endothelium-derived contracting and relaxing factors and oxidative stress. Studies have shown that placenta-derived factors [antiangiogenic factors, microparticles (MPs), cell-free nucleic acids] are released into the maternal circulation and act on the vascular wall to modify the secretory capacity of endothelial cells and alter the responsiveness of vascular smooth muscle cells to constricting and relaxing stimuli. These molecules signal their deleterious effects on the maternal vascular wall via pathways that provide the molecular basis for novel and effective therapeutic interventions.
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