Journal
TRENDS IN MOLECULAR MEDICINE
Volume 21, Issue 7, Pages 450-460Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.05.002
Keywords
GABA(A) alpha 5; GABA(B) receptor; hippocampus; memory; tonic inhibition; prefrontal cortex
Funding
- McKnight Brain Research Foundation
- McKnight Brain Institute
- [AG029421]
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Alterations in inhibitory interneurons contribute to cognitive deficits associated with several psychiatric and neurological diseases. Phasic and tonic inhibition imparted by 7-aminobutyric acid (GABA) receptors regulates neural activity and helps to establish the appropriate network dynamics in cortical circuits that support normal cognition. This review highlights basic science demonstrating that inhibitory signaling is altered in aging, and discusses the impact of age-related shifts in inhibition on different forms of memory function, including hippocampus-dependent spatial reference memory and prefrontal cortex (PFC)-dependent working memory. The clinical appropriateness and tractability of select therapeutic candidates for cognitive aging that target receptors mediating inhibition are also discussed.
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