Journal
TRENDS IN MOLECULAR MEDICINE
Volume 21, Issue 8, Pages 492-503Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.06.003
Keywords
conjunctiva; lung; intestine; differentiation; goblet cells; SPDEF
Funding
- V Foundation
- Sidney Kimmel Foundation
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Many organs throughout the body maintain epithelial homeostasis by employing a mucosal barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells are largely responsible for secreting components of this mucosal barrier and represent a major cellular component of the innate defense system. In this review we summarize what is known about the signaling pathways that control goblet cell differentiation in the intestine, the lung, and the ocular surface, and we discuss a novel functional role for goblet cells in mucosal epithelial immunology. We highlight the cell type-specificity of the circuitry regulating goblet cell differentiation and shed light on how changes to these pathways lead to altered goblet cell function, a prominent feature of mucosa-associated diseases.
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