Journal
TRENDS IN MOLECULAR MEDICINE
Volume 21, Issue 8, Pages 473-481Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.05.006
Keywords
germline genome editing; CRISPR/Cas9; ethics; genome engineering; embryonic stem cells
Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [26460586]
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Genetically modifying eggs, sperm, and zygotes ('germline' modification) can impact on the entire body of the resulting individual and on subsequent generations. With the advent of genome-editing technology, human germline gene modification is no longer theoretical. Owing to increasing concerns about human germline gene modification, a voluntary moratorium on human genome-editing research and/or the clinical application of human germline genome editing has recently been called for. However, whether such research should be suspended or encouraged warrants careful consideration. The present article reviews recent research on mammalian germline genome editing, discusses the importance of public dialogue on the socioethical implications of human germline genome-editing research, and considers the relevant guidelines and legislation in different countries.
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