Journal
TRENDS IN MOLECULAR MEDICINE
Volume 21, Issue 2, Pages 98-108Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.12.006
Keywords
-
Funding
- University Grants Committee Areas of Excellence Scheme of the Hong Kong SAR Government [AoE/M-04/06]
- Sequenom, Inc.
Ask authors/readers for more resources
The discovery of cell-free fetal DNA in maternal plasma opened up new possibilities for noninvasive prenatal testing (NIPT). Conceptual advances in single-molecule counting have resulted in robust methods for the NIPT of fetal chromosomal aneuploidies and subchromosomal aberrations. Such methods are employed worldwide and are among the most rapidly adopted genomic tests. Furthermore, approaches for fetal whole-genome sequencing from maternal plasma, as well as for targeted detection of many single-gene disorders, have been reported. Recently, fetal methylome and transcriptome sequencing from maternal plasma have also been achieved, potentially allowing fetal physiological and pathological processes to be monitored noninvasively using maternal blood. These advances herald exciting future applications in prenatal medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available