Journal
TRENDS IN MICROBIOLOGY
Volume 23, Issue 7, Pages 401-407Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2015.02.009
Keywords
collateral sensitivity; antibiotic resistance; experimental evolution; cross-resistance; multidrug resistance
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Funding
- Lendulet Programme of the Hungarian Academy of Sciences
- Wellcome Trust
- European Research Council
- Hungarian Academy of Sciences Postdoctoral Fellowship Programme
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Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it could be exploited for the development of alternative antimicrobial strategies.
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