Journal
TRENDS IN MICROBIOLOGY
Volume 23, Issue 4, Pages 212-224Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.12.008
Keywords
human immunodeficiency virus 1 (HIV-1); human leukocyte antigen (HLA) class I; CD8(+) T-lymphocyte (CTL); evolution; adaptation; immune escape
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- CIHR
- Michael Smith Foundation for Health Research (MSFHR)
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HIV-1 develops specific mutations within its genome that allow it to escape detection by human leukocyte antigen (HLA) class l-restricted immune responses, notably those of CD8(+) cytotoxic T lymphocytes (CTL). HLA thus represents a major force driving the evolution and diversification of HIV-1 within individuals and at the population level. Importantly, the study of HIV-1 adaptation to HLA also represents an opportunity to identify what qualities constitute an effective immune response, how the virus in turn adapts to these pressures, and how we may harness this information to design HIV-1 vaccines that stimulate effective cellular immunity.
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