Journal
TRENDS IN MICROBIOLOGY
Volume 23, Issue 3, Pages 154-163Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.12.003
Keywords
innate immunity; interferon; dynamin-like GTPase; primate evolution; influenza; HIV-1
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Funding
- German Science Foundation [KO 1579/8-2, KO 1579/9-1, SCHW 632/15-1, STA 338/13-1]
- Land Baden-Wurttemberg
- Federal Ministry of Education and Research (FluResearchNet)
- European Union (FLUINNATE)
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The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
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