Journal
TRENDS IN MICROBIOLOGY
Volume 23, Issue 1, Pages 44-54Publisher
CELL PRESS
DOI: 10.1016/j.tim.2014.10.002
Keywords
antimicrobial resistance; plasmid; transposon; colocation; coselection; cotransfer
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Funding
- German Federal Ministry of Education and Research (BMBF) through the German Aerospace Center (DLR) [01KI1014D, 01KI1301D]
- Major State Basic Research Development Program of China (973 Program) [2013CB127200]
- National Natural Science Foundation of China [31302145, 31201862]
- Friedrich-Loeffler-Institut (FLI)
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Most antimicrobial resistance genes known so far to occur in staphylococci of animal origin confer resistance to a specific class of antimicrobial agents or to selected members within such a class. However, there are also a few examples of multidrug resistance (MDR) genes that confer resistance to antimicrobial agents of different classes by either target site methylation or active efflux via ATP-binding cassette (ABC) transporters. The present review provides an overview of these MDR genes with particular reference to those genes involved in resistance to critically or highly important antimicrobial agents used in human and veterinary medicine. Moreover, their location on mobile genetic elements and colocated resistance genes, which may play a role in coselection and persistence of the MDR genes, are addressed.
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