Journal
PEDIATRICS
Volume 125, Issue 5, Pages 1031-1041Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2009-3301
Keywords
sepsis; septic shock; developmental influence; hemodynamics; coagulation cascade; immune function
Categories
Funding
- National Institutes of Health [K12HD047349, R01GM064619, 1 RC 1HL100474-01, RO1HL097361, RO1GM066839, UL1RR024986]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD047349, K08HD062142] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024986] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [RC1HL100474, R01HL097361] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM064619, K08GM077432, R01GM066839] Funding Source: NIH RePORTER
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Invasion of the human by a pathogen necessitates an immune response to control and eradicate the microorganism. When this response is inadequately regulated, systemic manifestations can result in physiologic changes described as sepsis. Recognition, diagnosis, and management of sepsis remain among the greatest challenges shared by the fields of neonatology and pediatric critical care medicine. Sepsis remains among the leading causes of death in both developed and underdeveloped countries and has an incidence that is predicted to increase each year. Despite these sobering statistics, promising therapies derived from preclinical models have universally failed to obviate the substantial mortality and morbidity associated with sepsis. Thus, there remains a need for well-designed epidemiologic and mechanistic studies of neonatal and pediatric sepsis to improve our understanding of the causes (both early and late) of deaths attributed to the syndrome. In reviewing the definitions and epidemiology, developmental influences, and regulation of the host response to sepsis, it is anticipated that an improved understanding of this host response will assist clinician-investigators in identifying improved therapeutic strategies. Pediatrics 2010;125:1031-1041
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