Journal
TRENDS IN MICROBIOLOGY
Volume 23, Issue 2, Pages 83-90Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.10.004
Keywords
virus; emergence; evolution; biocontrol; rabbit
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Funding
- Swiss National Science Foundation [P2ZHP3_151594]
- National Health and Medical Research Council (NHMRC) Australia
- National Institutes of Health (NIH) [R01 AI093804-01A1]
- Australian Research Council (ARC) [DP140103362]
- Swiss National Science Foundation (SNF) [P2ZHP3_151594] Funding Source: Swiss National Science Foundation (SNF)
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Although viral emergence is commonly associated with cross-species transmission, the processes and determinants of viral evolution in a novel host environment are poorly understood. We address key questions in virus emergence and evolution using data generated from two unique natural experiments: the deliberate release of myxoma virus (MYXV) and rabbit hemorrhagic disease virus (RHDV) as biological control (biocontrol) agents against the European rabbit in Australia, and which have been of enormous benefit to Australia's ecosystem and agricultural industries. Notably, although virulence evolution in MYXV and RHDV followed different trajectories, a strongly parallel evolutionary process was observed in Australia and Europe. These biocontrol agents were also characterized by a lack of transmission to nontarget host species, suggesting that there are major barriers to successful emergence.
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