Journal
TRENDS IN IMMUNOLOGY
Volume 36, Issue 10, Pages 605-613Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.08.008
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Funding
- NINDS NIH HHS [R01 NS071008, R01 NS084298] Funding Source: Medline
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Neuronal communication underlies all brain activity and the genesis of complex behavior. Emerging research has revealed an unexpected role for immune molecules in the development and plasticity of neuronal synapses. Moreover microglia, the resident immune cells of the brain, express and secrete immune-related signaling molecules that alter synaptic transmission and plasticity in the absence of inflammation. When inflammation does occur, microglia modify synaptic connections and synaptic plasticity required for learning and memory. Here we review recent findings demonstrating how the dynamic interactions between neurons and microglia shape the circuitry of the nervous system in the healthy brain and how altered neuron-microglia signaling could contribute to disease.
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