Journal
TRENDS IN IMMUNOLOGY
Volume 36, Issue 4, Pages 257-264Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.02.007
Keywords
T cell metabolism; glycolysis; IDO; PD-1; CTLA4; tumor microenvironment; antitumor immunity; checkpoint blockade
Categories
Funding
- Wade F. B. Thompson Clinical and Laboratory Integration Program grant from the Cancer Research Institute
- German Research Foundation (Deutsche Forschungsgemeinschaft)
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T cell metabolism has a central role in supporting and shaping immune responses and may have a key role in antitumor immunity. T cell metabolism is normally held under tight regulation in an immune response of glycolysis to promote effector T cell expansion and function. However, tumors may deplete nutrients, generate toxic products, or stimulate conserved negative feedback mechanisms, such as through Programmed Cell Death 1 (PD-1), to impair effector T cell nutrient uptake and metabolic fitness. In addition, regulatory T cells are favored in low glucose conditions and may inhibit antitumor immune responses. Here, we review how the tumor microenvironment modifies metabolic and functional pathways in T cells and how these changes may uncover new targets and challenges for cancer immunotherapy and treatment.
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