Journal
PEDIATRICS
Volume 123, Issue 3, Pages e465-e470Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2008-2012
Keywords
lung compliance; neonatal resuscitation; ventilation
Categories
Funding
- American Academy of Pediatrics
- Department of Pediatrics, University of Virginia
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OBJECTIVE. The standard technique for positive-pressure ventilation is to regulate the breath size by varying the pressure applied to the bag. Investigators have argued that consistency of peak inspiratory pressure is important. However, research shows that excessive tidal volume delivered with excessive pressure injures preterm lungs, which suggests that inspiratory pressure should be varied during times of changing compliance, such as resuscitation of newborns or treatment after surfactant delivery. METHODS. We modified a computerized lung model (ASL5000 [IngMar Medical, Pittsburgh, PA]) to simulate the functional residual capacity of a 3-kg neonate with apnea and programmed it to change compliance during ventilation. Forty-five professionals were blinded to randomized compliance changes while using a flow-inflating bag, a self-inflating bag, and a T-piece resuscitator. We instructed subjects to maintain a constant inflation volume, first while blinded to delivered volume and then with volume displayed, with all 3 devices. RESULTS. Subjects adapted to compliance changes by adjusting inflation pressure more effectively when delivered volume was displayed. When only pressure was displayed, sensing of compliance changes occurred only with the self-inflating bag. When volume was displayed, adjustments to compliance changes occurred with all 3 devices, although the self-inflating bag was superior. CONCLUSIONS. In this lung model, volume display permitted far better detection of display of only pressure. Devices for administration of positive-pressure ventilation than pressure. Pediatrics 2009; 123: e465-e470
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