Journal
TRENDS IN GENETICS
Volume 31, Issue 10, Pages 576-586Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.07.003
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Funding
- Claudia Adams Barr Award
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Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptomic, and proteomic levels, and discuss their applications in cancer research.
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