Journal
TRENDS IN GENETICS
Volume 31, Issue 9, Pages 500-508Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.05.003
Keywords
IKAROS; hematopoiesis; transcription elongation; transcription termination; P-TEFb; NuRD
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Funding
- Canadian Institute of Health Research [CIHR MOP133420]
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Transcription factors are important determinants of lineage specification during hematopoiesis. They favor recruitment of cofactors involved in epigenetic regulation, thereby defining patterns of gene expression in a development- and lineage-specific manner. Additionally, transcription factors can facilitate transcription preinitiation complex (PIC) formation and assembly on chromatin. Interestingly, a few lineage-specific transcription factors, including IKAROS, also regulate transcription elongation. IKAROS is a tumor suppressor frequently inactivated in leukemia and associated with a poor prognosis. It forms a complex with the nucleosome remodeling and deacetylase (NuRD) complex and the positive transcription elongation factor b (P-TEFb), which is required for productive transcription elongation. It has also been reported that IKAROS interacts with factors involved in transcription termination. Here we review these and other recent findings that establish IKAROS as the first transcription factor found to act as a multifunctional regulator of the transcription cycle in hematopoietic cells.
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