Journal
ACTA HISTOCHEMICA
Volume 117, Issue 4-5, Pages 339-354Publisher
ELSEVIER GMBH
DOI: 10.1016/j.acthis.2015.02.007
Keywords
Circulating biomarker; MicroRNA; Pediatric cancer
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Funding
- Italian Ministry of Education, University and Research (MIUR) [PON01_01078]
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A better understanding of pediatric tumor biology is needed to allow the development of less toxic and more efficient therapies, as well as to provide novel reliable biomarkers for diagnosis and risk stratification. The emerging role of microRNAs in controlling key pathways implicated in tumorigenesis makes their use in diagnostics a powerful novel tool for the early detection, risk assessment and prognosis, as well as for the development of innovative anticancer therapies. This perspective would be more urgent for the clinical management of pediatric cancer. In this review, we focus on the involvement of microRNAs in the biology of the main childhood tumors, describe their clinical significance and discuss their potential use as novel therapeutic tools and targets. (C) 2015 Elsevier GmbH. All rights reserved.
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