4.0 Article

Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Journal

PEDIATRIC TRANSPLANTATION
Volume 13, Issue 5, Pages 632-635

Publisher

WILEY
DOI: 10.1111/j.1399-3046.2008.01027.x

Keywords

adenovirus; ganciclovir; hemorrhagic cystitis; stem-cell transplantation

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A nine-yr-old girl developed AdV-associated HC after bone marrow transplantation. Intravenous GCV markedly reduced urinary AdV DNA loads and improved clinical findings. This appeared to result partly from a high concentration of GCV in urine. GCV may be effective for AdV-induced HC without definitive disseminated infection.

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