Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 26, Issue 2, Pages 69-74Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.11.004
Keywords
osteoporosis; osteohnmunology; gut microbiota
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Funding
- Swedish Research Council
- Swedish Foundation for Strategic Research
- COMBINE
- Avtal om Lakarutbildning och Forskning/Lakarutbildningsavtalet research grant in Gothenburg
- Lundberg Foundation
- Torsten and Ragnar Soderberg Foundation
- Novo Nordisk Foundation
- Magnus Bergvall Foundation
- Ake Wiberg Foundation
- Novo Nordisk Fonden [NNF13OC0005785, NNF14OC0010513] Funding Source: researchfish
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The gut microbiota (GM), the commensal bacteria living in our intestine, performs numerous useful functions, including modulating host metabolism and immune status. Recent studies demonstrate that the GM is also a regulator of bone mass and it is proposed that the effect of the GM on bone mass is mediated via effects on the immune system, which in turn regulates osteoclastogenesis. Under normal conditions, the skeleton is constantly remodeled by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCLs), and imbalances in this process may lead to osteoporosis. Here we review current knowledge on the possible role for the GM in the regulation of bone metabolism and propose that the GM might be a novel therapeutic target for osteoporosis and fracture prevention.
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