Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 26, Issue 6, Pages 305-314Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2015.03.010
Keywords
PGC-1; coactivators; skeletal muscle; metabolism; atrophy; hypertrophy
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Funding
- Swedish Research Council
- Novo Nordisk Foundation (Denmark)
- Malin and Lennart Philipson Foundation (Sweden)
- Diabetes Research and Wellness Foundation
- Marie Curie Career Integration grant
- Wenner-Gren Foundations
- Novo Nordisk Fonden [NNF12OC1016062] Funding Source: researchfish
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Physical exercise promotes complex adaptations in skeletal muscle that benefit various aspects of human health. Many of these adaptations are coordinated at the gene expression level by the concerted action of transcriptional regulators. Peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1 (PGC-1) proteins play a prominent role in skeletal muscle transcriptional reprogramming induced by numerous stimuli. PGC-1s are master coactivators that orchestrate broad gene programs to modulate fuel supply and mitochondrial function, thus improving cellular energy metabolism. Recent studies unveiled novel biological functions for PGC-1s that extend well beyond skeletal muscle bioenergetics. Here we review recent advances in our understanding of PGC-1 actions in skeletal muscle, with special focus on their systemic effects.
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