Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 26, Issue 8, Pages 404-410Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2015.06.002
Keywords
cardiac contraction; glucose uptake; signaling pathway; diabetes; heart
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Funding
- Netherlands Organization of Scientific Research (NWO-ALW) [864.10.007]
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Contraction-induced translocation of glucose transporter type-4 (GLUT4) to the sarcolemma is essential to stimulate cardiac glucose uptake during increased energy demand. As such, this process is a target for therapeutic strategies aiming at increasing glucose uptake in insulin-resistant and/or diabetic hearts. AMP-activated protein kinase (AMPK) and its upstream kinases form part of a signaling axis essential for contraction-induced GLUT4 translocation. Recently, activation of protein kinase-D1 (PKD1) was also shown to be as obligatory for contraction-induced GLUT4 translocation in cardiac muscle. However, contraction-induced PKD1 activation in this context occurs independently from AMPK signaling, suggesting that contraction-induced GLUT4 translocation requires the input of two separate signaling pathways. Necessity for dual input would more tightly couple GLUT4 translocation to stimuli that are inherent to cardiac contraction.
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