Journal
TRENDS IN COGNITIVE SCIENCES
Volume 19, Issue 10, Pages 567-578Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2015.08.002
Keywords
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Funding
- National Institutes of Health [RC1-DC010720]
- American Tinnitus Association
- Skirball Foundation
- Tinnitus Research Initiative
- Tinnitus Research Consortium
- Belgian American Educational Foundation (BAEF)
- Deutsche Forschungsgemeinschaft [PL 321/10-1, PL 321/11-1]
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Tinnitus and chronic pain are sensory-perceptual disorders associated with negative affect and high impact on well-being and behavior. It is now becoming increasingly clear that higher cognitive and affective brain systems are centrally involved in the pathology of both disorders. We propose that the ventromedial prefrontal cortex and the nucleus accumbens are part of a central 'gatekeeping' system in both sensory modalities, a system which evaluates the relevance and affective value of sensory stimuli and controls information flow via descending pathways. If this frontostriatal system is compromised, long-lasting disturbances are the result. Parallels in both systems are striking and mutually informative, and progress in understanding central gating mechanisms might provide a new impetus to the therapy of tinnitus and chronic pain.
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