Journal
TRENDS IN CELL BIOLOGY
Volume 25, Issue 9, Pages 499-513Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2015.05.002
Keywords
extracellular matrix; stem cells; regeneration; primary cilia; Wnt; Notch
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Funding
- National Institutes of Health (NIH) [CA132809, EYO226116]
- Danish Council for Independent Research|Natural Sciences
- Japan Society for Promotion of Science (JSPS) Postdoctoral Fellowships
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The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta (TGF beta), and Notch pathways.
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