Journal
TRENDS IN CELL BIOLOGY
Volume 25, Issue 11, Pages 697-707Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2015.07.010
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Funding
- National Science Foundation [IOS-1052333]
- National Institutes of Health [R01 GM072562]
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Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur.
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